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Beilstein J. Org. Chem. 2014, 10, 2293–2306, doi:10.3762/bjoc.10.239
Graphical Abstract
Figure 1: Covalent cross-linking of a I6S/U4S or G6S/U4S base pair within duplex ODN 1∙2 (a) by bis-alkylatio...
Figure 2: Characterization of HPLC-purified cross-linked duplex 1I6S-Et-S4U2 (a) by denaturing anion exchange...
Figure 3: Characterization of HPLC-purified cross-linked duplex 1G6S-Et-S4U2 (a) by denaturing anion exchange...
Figure 4: Opening and traceless linker removal of the cross-linked duplexes 1I6S-Et-S4U2 and 1G6S-Et-S4U2 by ...
Figure 5: UV time course of opening of the cross-link in duplex 1I6S-Et-S4U2 with the thiol nucleophiles DTT ...
Figure 6: Competition binding of M.TaqI to DNA with unlocked and locked target base pairs. Increasing amounts...